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Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL.

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作者单位: Department of Cancer Research, Tumor Stroma Interactions, Luxembourg Institute of Health, Luxembourg, Luxembourg. [1] Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. [2] Laboratory of Cancer Signaling, GIGA Stem Cells, University of Liège, Liège, Belgium. [3] Department of Cancer Research, Cancer Metabolism Group, Luxembourg Institute of Health, Luxembourg, Luxembourg. [4] Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Solna, Sweden. [5] Department of Infection and Immunity, Proteomics of Cellular Signaling, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. [6] Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy. [7] Haematology Department, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France. [8] Laboratoire d'hématologie, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg. [9] Département d'hémato-oncologie, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg. [10] Luxembourg Institute of Health, Luxembourg, Luxembourg. [11] Department of Life Sciences and Medicine, University of Luxembourg, Belvaux, Luxembourg. [12] Department of Infection and Immunity, Immuno-Pharmacology and Interactomics, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. [13] Department of Cancer Research, Multiomics Data Science, Luxembourg Institute of Health, Luxembourg, Luxembourg. [14] Department of Oncology and Metabolism, Weston Park Cancer Centre, The Medical School, University of Sheffield, Sheffield, United Kingdom. [15] WELBIO Department, WEL Research Institute, Wavre, Belgium. [16] Laboratory of Clinical Cell Therapy, ULB-Research Cancer Center, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium. [17] Regenerative Nanomedicine Laboratory (UMR1260), Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, INSERM-University of Strasbourg, Strasbourg, France. [18]
DOI 10.1182/blood.2022017839
PMID 37084385
发布时间 2024-03-24
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Blood

Blood

2023年141卷26期

3166-3183页

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