Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease.

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作者： Christopher Daniel,Morrone ^[1] ; Radha,Raghuraman ^[2] ; S Abid,Hussaini ^[3] ; Wai Haung,Yu ^[4]

作者单位： Brain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, M5T 1R8, Canada. Christopher.Morrone@camh.ca. ^[1] Taub Institute, Columbia University Irving Medical Center, 630W 168th Street, New York, NY, 10032, USA. ^[2] Department of Pathology and Cell Biology, Columbia University Irving Medical Center, 630W 168th Street, New York, NY, 10032, USA. ^[3] Taub Institute, Columbia University Irving Medical Center, 630W 168th Street, New York, NY, 10032, USA. sah2149@cumc.columbia.edu. ^[4] Department of Pathology and Cell Biology, Columbia University Irving Medical Center, 630W 168th Street, New York, NY, 10032, USA. sah2149@cumc.columbia.edu. ^[5] Brain Health Imaging Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, M5T 1R8, Canada. WaiHaung.Yu@camh.ca. ^[6] Geriatric Mental Health Research Services, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, M5T 1R8, Canada. WaiHaung.Yu@camh.ca. ^[7] Department of Pharmacology and Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. WaiHaung.Yu@camh.ca. ^[8]

关键词 Alzheimer’s disease Autophagy Proteostasis Sleep Tau Unfolded protein response β-amyloid

主题词人类(Humans);阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);睡眠(Sleep);神经元(Neurons);tau蛋白质类(tau Proteins)

DOI 10.1186/s13024-023-00617-4

PMID 37085942

发布时间 2023-05-10

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