Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling.

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作者： Richard,Cowan ^[1] ; Martina,Trokter ^[2] ; Arkadiusz,Oleksy ^[2] ; Marina,Fedorova ^[2] ; Kovilen,Sawmynaden ^[2] ; Thomas,Worzfeld ^[3] ; Stefan,Offermanns ^[4] ; David,Matthews ^[2] ; Mark D,Carr ^[1] ; Gareth,Hall ^[5]

作者单位： Department of Molecular and Cell Biology, Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, UK. ^[1] LifeArc, Centre for Therapeutics Discovery, Stevenage, UK. ^[2] Institute of Pharmacology, University of Marburg, Marburg, Germany; Department of Pharmacology, Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. ^[3] Department of Pharmacology, Max-Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. ^[4] Department of Molecular and Cell Biology, Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, UK. Electronic address: gh126@leicester.ac.uk. ^[5]

关键词 cancer multiple sclerosis phage display semaphorin single-domain antibody (sdAb, nanobody, VHH)

主题词动物(Animals);小鼠(Mice);受体, 细胞表面(Receptors, Cell Surface);信号素类(Semaphorins);信号传导(Signal Transduction);细胞黏附分子(Cell Adhesion Molecules)

DOI 10.1016/j.jbc.2023.104740

PMID 37088134

发布时间 2023-07-06

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