Structural insights into thrombolytic activity of destabilase from medicinal leech.

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作者： Egor,Marin ^[1] ; Daniil A,Kornilov ^[2] ; Sergey S,Bukhdruker ^[1] ; Vladimir A,Aleksenko ^[1] ; Valentin A,Manuvera ^[1] ; Egor V,Zinovev ^[1] ; Kirill V,Kovalev ^[3] ; Mikhail B,Shevtsov ^[1] ; Anna A,Talyzina ^[4] ; Pavel A,Bobrovsky ^[1] ; Pavel K,Kuzmichev ^[1] ; Alexey V,Mishin ^[5] ; Ivan Y,Gushchin ^[1] ; Vassili N,Lazarev ^[3] ; Valentin I,Borshchevskiy ^[1]

作者单位： Moscow Institute of Physics and Technology, Dolgoprudny, Russia. ^[1] Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands. ^[2] Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia. ^[3] EMBL Outstation Hamburg, c/o DESY, Hamburg, Germany. ^[4] Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA. ^[5] Moscow Institute of Physics and Technology, Dolgoprudny, Russia. borshchevskiy.vi@phystech.edu. ^[6] Joint Institute for Nuclear Research, Dubna, Russia. borshchevskiy.vi@phystech.edu. ^[7]

主题词动物(Animals);药用水蛭(Hirudo medicinalis);胞壁质酶(Muramidase);内肽酶类(Endopeptidases);水蛭(Leeches);纤维蛋白溶解药(Fibrinolytic Agents)

DOI 10.1038/s41598-023-32459-x

PMID 37095116

发布时间 2023-05-10

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