Impact of sarcopenia indexes on survival and severe immune acute toxicity in metastatic non-small cell lung cancer patients treated with PD-1 immune checkpoint inhibitors.

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作者： Elisabeth,Ashton ^[1] ; Jennifer,Arrondeau ^[2] ; Anne,Jouinot ^[3] ; Pascaline,Boudou-Rouquette ^[4] ; Laure,Hirsch ^[4] ; Olivier,Huillard ^[4] ; Guillaume,Ulmann ^[5] ; Audrey,Lupo-Mansuet ^[6] ; Diane,Damotte ^[6] ; Marie,Wislez ^[7] ; Marco,Alifano ^[8] ; Jérôme,Alexandre ^[4] ; François,Goldwasser ^[9]

作者单位： Department of Medical Oncology, Cochin Hospital, Paris Cancer Institute CARPEM, Université Paris Cité, APHP.Centre, 75014 Paris, France. Electronic address: ashton.elisa@gmail.com. ^[1] Department of Medical Oncology, Cochin Hospital, Paris Cancer Institute CARPEM, Université Paris Cité, APHP.Centre, 75014 Paris, France; Immunomodulatory Therapies Multidisciplinary Study Group (CERTIM), Cochin Hospital, Université Paris Cité, APHP.Centre, 75014 Paris, France. Electronic address: jennifer.arrondeau@aphp.fr. ^[2] Université Paris Cité, Institut Cochin, INSERM U-1016, CNRS UMR-8104, 75014 Paris, France; Department of Endocrinology, Cochin Hospital, Université Paris Cité, APHP.Centre, 75014 Paris, France. ^[3] Department of Medical Oncology, Cochin Hospital, Paris Cancer Institute CARPEM, Université Paris Cité, APHP.Centre, 75014 Paris, France; Immunomodulatory Therapies Multidisciplinary Study Group (CERTIM), Cochin Hospital, Université Paris Cité, APHP.Centre, 75014 Paris, France. ^[4] Department of Clinical Chemistry, Cochin Hospital, Université Paris Cité, APHP.Centre, 75014 Paris, France. ^[5] Department of Pathology, Cochin Hospital, Université Paris Cité, APHP.Centre, 75014 Paris, France. ^[6] Department of Respiratory Medicine and Thoracic Oncology, Paris Cancer Institute CARPEM, Université Paris Cité, APHP.Centre, 75014 Paris, France. ^[7] Department of Thoracic Surgery, Paris Cancer Institute CARPEM, Université Paris Cité, APHP.Centre, 75014 Paris, France. ^[8] Department of Medical Oncology, Cochin Hospital, Paris Cancer Institute CARPEM, Université Paris Cité, APHP.Centre, 75014 Paris, France; Immunomodulatory Therapies Multidisciplinary Study Group (CERTIM), Cochin Hospital, Université Paris Cité, APHP.Centre, 75014 Paris, France. Electronic address: francois.goldwasser@aphp.fr. ^[9]

关键词 Cystatin C Immune checkpoint inhibitors/adverse effects Immune checkpoint inhibitors/toxicity Lung neoplasms Sarcopenia