Omicron Spike Protein is Vulnerable to Reduction.

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第一作者： Zhong,Yao

第一单位： Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address: zhong.yao@utoronto.ca.

作者： Zhong,Yao ^[1] ; Betty,Geng ^[2] ; Edyta,Marcon ^[3] ; Shuye,Pu ^[3] ; Hua,Tang ^[3] ; John,Merluza ^[4] ; Alexander,Bello ^[4] ; Jamie,Snider ^[2] ; Ping,Lu ^[5] ; Heidi,Wood ^[4] ; Igor,Stagljar ^[6]

作者单位： Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address: zhong.yao@utoronto.ca. ^[1] Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 3E1, Canada. ^[2] Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada. ^[3] Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada. ^[4] Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. ^[5] Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada; Mediterranean Institute for Life Sciences, Meštrovićevo Šetalište 45, HR-21000 Split, Croatia. Electronic address: igor.stagljar@utoronto.ca. ^[6]

关键词 ACE2 SARS-CoV-2 binding disulfide receptor binding motif (RBM)

主题词人类(Humans);生物学鉴定法(Biological Assay);突变(Mutation);蛋白质结合(Protein Binding);氧化还原(Oxidation-Reduction);蛋白质稳定性(Protein Stability)

DOI 10.1016/j.jmb.2023.168128

PMID 37100168

发布时间 2023-06-22

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准确一般字义偏差语意偏离译文作用小提交