Tumor-targeting engineered probiotic Escherichia coli Nissle 1917 inhibits colorectal tumorigenesis and modulates gut microbiota homeostasis in mice.

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作者： Haibo,Tang ^[1] ; Tuoyu,Zhou ^[1] ; Weilin,Jin ^[2] ; Simin,Zong ^[1] ; Tursunay,Mamtimin ^[1] ; El-Sayed,Salama ^[3] ; Byong-Hun,Jeon ^[4] ; Pu,Liu ^[1] ; Huawen,Han ^[5] ; Xiangkai,Li ^[6]

作者单位： Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou University, Lanzhou, China. ^[1] Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, China. ^[2] Department of Occupational and Environmental Health, School of Public Health, Lanzhou University, Lanzhou, China. ^[3] Department of Earth Resources and Environmental Engineering, Hanyang University, Seoul, Republic of Korea. ^[4] Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou University, Lanzhou, China; State Key Laboratory of Grassland Agro-ecosystems, Center for Grassland Microbiome, Lanzhou University, Lanzhou, China. Electronic address: hanhuawen@lzu.edu.cn. ^[5] Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Science, Lanzhou University, Lanzhou, China. Electronic address: xkli@lzu.edu.cn. ^[6]

关键词 AOM/DSS model Engineered probiotic Escherichia coli Nissle 1917 Gut microbiota Tumor-targeting treatment