Identifying novel risk conferring genes involved in glycosylation processes with familial schizophrenia in an Indian cohort: Prediction of ADAMTS9 gene variant for structural stability.

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作者： Bipin Raj,Shekhar ^[1] ; Karishma,Rupani ^[2] ; Shubhangi Raghunath,Parkar ^[2] ; Ajita Sunil,Nayak ^[2] ; Bajarang Vasant,Kumbhar ^[3] ; Satyajeet P,Khare ^[4] ; Shyla,Menon ^[5] ; Harshavardhan,Gawde ^[6] ; Dhanjit Kumar,Das ^[7]

作者单位： Genetic Research Centre, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, Maharashtra 400012, India; Stem Cell Biology, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, Maharashtra 400012, India. ^[1] Department of Psychiatry, Seth GS Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India. ^[2] Department of Biological Sciences, Sunandan Divatia School of Science, NMIMS University (Deemed), Mumbai, Maharashtra 400056, India. ^[3] Symbiosis School of Biological Sciences, Symbiosis International University, Pune, Maharashtra 412115, India. ^[4] Stem Cell Biology, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, Maharashtra 400012, India. ^[5] Genetic Research Centre, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, Maharashtra 400012, India. ^[6] Stem Cell Biology, ICMR-National Institute for Research in Reproductive and Child Health, Parel, Mumbai, Maharashtra 400012, India. Electronic address: dasd@nirrch.res.in. ^[7]

关键词 ADAMTS9 Exome sequencing Genetic variants Glycosylation Molecular dynamics simulation Schizophrenia

主题词人类(Humans);精神分裂症(Schizophrenia);糖基化(Glycosylation);疾病遗传易感性(Genetic Predisposition to Disease);突变, 误义(Mutation, Missense);精神病(Psychotic Disorders);膜蛋白质类(Membrane Proteins)

DOI 10.1016/j.gene.2023.147443

PMID 37105505

发布时间 2023-05-29

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