The impact of PIK3CA mutations and PTEN expression on the effect of neoadjuvant therapy for postmenopausal luminal breast cancer patients.

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第一作者： Shouko,Hayama

第一单位： Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba-Shi, Chiba, 260-8677, Japan.;Department of Breast Surgery, Chiba Cancer Center, 666-2 Nitona, Chuo-Ku, Chiba-Shi, Chiba, 260-8717, Japan.

作者： Shouko,Hayama ^[1] ; Rikiya,Nakamura ^[2] ; Takayuki,Ishige ^[3] ; Takafumi,Sangai ^[4] ; Masahiro,Sakakibara ^[5] ; Hiroshi,Fujimoto ^[6] ; Emi,Ishigami ^[6] ; Takahito,Masuda ^[6] ; Ayako,Nakagawa ^[6] ; Ryotaro,Teranaka ^[6] ; Satoshi,Ota ^[7] ; Sakae,Itoga ^[8] ; Naohito,Yamamoto ^[2] ; Takeshi,Nagashima ^[6] ; Masayuki,Otsuka ^[6]

作者单位： Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba-Shi, Chiba, 260-8677, Japan.;Department of Breast Surgery, Chiba Cancer Center, 666-2 Nitona, Chuo-Ku, Chiba-Shi, Chiba, 260-8717, Japan. ^[1] Department of Breast Surgery, Chiba Cancer Center, 666-2 Nitona, Chuo-Ku, Chiba-Shi, Chiba, 260-8717, Japan. ^[2] Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba-Shi, Chiba, 260-8677, Japan. ^[3] Department of Breast and Thyroid Surgery, Kitasato University School of Medicine, 1-15-1 Kitazato Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan. sangai@med.kitasato-u.ac.jp. ^[4] Departments of Breast Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan. ^[5] Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba-Shi, Chiba, 260-8677, Japan. ^[6] Department of Pathology, Chiba University Hospital, 1-8-1 Inohana, Chuo-Ku, Chiba-Shi, Chiba, 260-8677, Japan. ^[7] Department of Applied Genomics, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu Chiba, 292-0818, Japan. ^[8]

关键词 Breast neoplasms Neoadjuvant therapy PTEN Phosphohydrolase Phosphatidylinositol 3-Kinases/genetics Prognosis