Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability.

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作者： Tao,Wu ^[1] ; Xuan,Zhang ^[1] ; Xinxing,Liu ^[1] ; Xinyi,Cai ^[1] ; Tao,Shen ^[1] ; Dingguo,Pan ^[1] ; Rui,Liang ^[2] ; Rong,Ding ^[3] ; Ruixi,Hu ^[1] ; Jianhua,Dong ^[1] ; Furong,Li ^[4] ; Jinsha,Li ^[4] ; Lin,Xie ^[5] ; Chunlong,Wang ^[6] ; Shilei,Geng ^[1] ; Zhaoyu,Yang ^[1] ; Lu,Xing ^[7] ; YunFeng,Li ^[8]

作者单位： Department of Colorectal Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, No. 519, Kunzhou Road, Xishan District, Kunming, 650118, China. ^[1] College of Bioengineering, Chongqing University, Chongqing, China. ^[2] Department of Minimally Invasive Intervention, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China. ^[3] Department of Gastroenteroscopy, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China. ^[4] Department of Oncology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China. ^[5] Department of Radiology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China. ^[6] Department of Dermatology, Kunming Children's Hospital, Kunming, China. 914760716@qq.com. ^[7] Department of Colorectal Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, No. 519, Kunzhou Road, Xishan District, Kunming, 650118, China. liyunfeng@kmmu.edu.cn. ^[8]

关键词 Deficient mismatch repair (dMMR)Interleukin-1 beta (IL-1β)Metastatic colorectal cancer (mCRC)Myeloid-derived suppressor cells (MDSCs)Programmed cell death protein-1(PD-1)microsatellite instability-high (MSI-H)

主题词动物(Animals);小鼠(Mice);微卫星不稳定性(Microsatellite Instability);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);结直肠肿瘤(Colorectal Neoplasms);免疫组织化学(Immunohistochemistry);肿瘤微环境(Tumor Microenvironment)

DOI 10.1186/s12916-023-02866-y

PMID 37106440

发布时间 2023-05-01

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