Treatment of Diet-Induced Obese Rats with CB<sub>2</sub> Agonist AM1241 or CB<sub>2</sub> Antagonist AM630 Reduces Leptin and Alters Thermogenic mRNA in Adipose Tissue.

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第一作者： Lannie,O'Keefe

第一单位： Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.

作者： Lannie,O'Keefe ^[1] ; Teresa,Vu ^[2] ; Anna C,Simcocks ^[1] ; Kayte A,Jenkin ^[3] ; Michael L,Mathai ^[4] ; Andrew J,McAinch ^[5] ; Dana S,Hutchinson ^[6] ; Deanne H,Hryciw ^[7]

作者单位： Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia. ^[1] Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.;Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. ^[2] Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.;School of Science, Western Sydney University, Campbelltown, NSW 2560, Australia. ^[3] Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.;The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia. ^[4] Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.;Australian Institute for Musculoskeletal Science (AIMSS), Victoria University, Melbourne, VIC 8001, Australia. ^[5] Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. ^[6] Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.;School of Environment and Sciences, Griffith University, Nathan, QLD 4111, Australia.;Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia. ^[7]

关键词 AM1241 AM630 adipose tissue cannabinoid receptor 2 (CB2)diet-induced obesity (DIO)endocannabinoid system (ECS)inflammation