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Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity.

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第一作者： Wenming,Huang

第一单位： Max Planck Institute for Biology of Ageing, Cologne, Germany.

作者： Wenming,Huang ^[1] ; Chun,Kew ^[2] ; Stephanie de Alcantara,Fernandes ^[3] ; Anna,Löhrke ^[1] ; Lynn,Han ^[4] ; Constantinos,Demetriades ^[5] ; Adam,Antebi ^[6]

作者单位： Max Planck Institute for Biology of Ageing, Cologne, Germany. ^[1] Max Planck Institute for Biology of Ageing, Cologne, Germany.;Institute of Biochemistry II, Goethe-Universität, Frankfurt am Main, Germany. ^[2] Max Planck Institute for Biology of Ageing, Cologne, Germany.;Cologne Graduate School for Aging Research, Cologne, Germany. ^[3] Max Planck Institute for Biology of Ageing, Cologne, Germany.;Weill Medical College of Cornell University, New York, NY, USA. ^[4] Max Planck Institute for Biology of Ageing, Cologne, Germany.;Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany. ^[5] Max Planck Institute for Biology of Ageing, Cologne, Germany. aantebi@age.mpg.de.;Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany. aantebi@age.mpg.de. ^[6]

医学主题词动物(Animals);剪接体(Spliceosomes);长寿(Longevity);内含子(Introns);漂亮新小杆线虫蛋白质类(Caenorhabditis elegans Proteins);秀丽新小杆线虫(Caenorhabditis elegans);核糖核蛋白类(Ribonucleoproteins);哺乳动物(Mammals)

DOI 10.1038/s43587-022-00275-z

PMID 37118503

发布时间 2023-05-07

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Nature aging

2022年2卷9期

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Nature aging

2022年2卷9期

796-808页

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Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity.

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Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity.

Nature aging

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Nature aging

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