Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment.

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第一作者： Einat,Granot-Hershkovitz

第一单位： Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.

作者： Einat,Granot-Hershkovitz ^[1] ; Brian,Spitzer ^[2] ; Yunju,Yang ^[1] ; Wassim,Tarraf ^[2] ; Bing,Yu ^[3] ; Eric,Boerwinkle ^[4] ; Myriam,Fornage ^[5] ; Thomas H,Mosley ^[3] ; Charles,DeCarli ^[6] ; Bruce S,Kristal ^[3] ; Hector M,González ^[7] ; Tamar,Sofer ^[8]

作者单位： Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA. ^[1] Department of Medicine, Harvard Medical School, Boston, MA, USA. ^[2] Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. ^[3] Institute of Gerontology, Wayne State University, Detroit, MI, USA. ^[4] Human Genetics Center, School of Public Health University of Texas Health Science Center at Houston, Houston, TX, USA. ^[5] Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. ^[6] Department of Neurology, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. ^[7] Alzheimer's Disease Center, Department of Neurology, University of California, Davis, Sacramento, CA, USA. ^[8] Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. ^[9] Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA. tsofer@bidmc.harvard.edu. ^[10] Department of Medicine, Harvard Medical School, Boston, MA, USA. tsofer@bidmc.harvard.edu. ^[11] Department of Biostatistics, Harvard T.H Chan School of Public Health, Boston, MA, USA. tsofer@bidmc.harvard.edu. ^[12] Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA. tsofer@bidmc.harvard.edu. ^[13]

主题词人类(Humans);全基因组关联研究(Genome-Wide Association Study);衰老(Aging);基因座(Genetic Loci);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1038/s41398-023-02437-y

PMID 37120436

发布时间 2023-09-03

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准确一般字义偏差语意偏离译文作用小提交