SARS-CoV-2 M<sup>pro</sup> Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals.

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作者： Sizhu Amelia,Chen ^[1] ; Elena,Arutyunova ^[2] ; Jimmy,Lu ^[1] ; Muhammad Bashir,Khan ^[2] ; Wioletta,Rut ^[1] ; Mikolaj,Zmudzinski ^[2] ; Shima,Shahbaz ^[1] ; Jegan,Iyyathurai ^[3] ; Eman W,Moussa ^[3] ; Zoe,Turner ^[4] ; Bing,Bai ^[1] ; Tess,Lamer ^[2] ; James A,Nieman ^[1] ; John C,Vederas ^[1] ; Olivier,Julien ^[5] ; Marcin,Drag ^[6] ; Shokrollah,Elahi ^[7] ; Howard S,Young ^[5] ; M Joanne,Lemieux ^[6]

作者单位： Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. ^[1] Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada. ^[2] Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wroclaw, 50-370, Poland. ^[3] Department of Dentistry & Dental Hygiene, University of Alberta, Edmonton, Alberta T6G 2E1, Canada. ^[4] Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada. ^[5] Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada. ^[6] Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada. ^[7]

DOI 10.1021/acscentsci.3c00054

PMID 37122453

发布时间 2023-05-02

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ACS central science

2023年9卷4期

696-708页

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SARS-CoV-2 M<sup>pro</sup> Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals.

ACS central science

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ACS central science

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SARS-CoV-2 M<sup>pro</sup> Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals.

ACS central science

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ACS central science

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