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Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse.

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第一作者: James R W,Conway
第一单位: Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia.;St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.;Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland.;Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
作者单位: Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia.;St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.;Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland.;Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. [1] Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia.;St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.;Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. [2] Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia.;Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia. [3] Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia.;Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.;School of Clinical Medicine, UNSW Sydney, Randwick Clinical Campus, Sydney, NSW, Australia. [4] Department of Pharmacology and Therapeutics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.;CancerCare Manitoba Research Institute, Winnipeg, Manitoba, Canada. [5] Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia. [6] Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia.;St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia. [7] School of Clinical Medicine, Randwick Clinical Campus, UNSW Sydney, Centre for Healthy Ageing, Centenary Institute, Missenden Road, Sydney, NSW 2050, Australia.;Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia. [8] Laboratory for Intravital Imaging and Dynamics of Tumor Progression, VIB Center for Cancer Biology, KU Leuven, 3000 Leuven, Belgium.;Department of Oncology, KU Leuven, 3000 Leuven, Belgium. [9] Cancer Research UK Beatson Institute, Glasgow G611BD, UK.;School of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G611QH, UK. [10] Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia. [11] Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia.;St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.;Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.;Laboratory for Intravital Imaging and Dynamics of Tumor Progression, VIB Center for Cancer Biology, KU Leuven, 3000 Leuven, Belgium.;Intravital Imaging Expertise Center, VIB Center for Cancer Biology, KU Leuven, 3000 Leuven, Belgium. [12]
DOI 10.1126/sciadv.adf9063
PMID 37126544
发布时间 2025-05-30
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2023年9卷17期

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