Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer.

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第一作者： Shan-Shan,Jiang

第一单位： Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China.

作者： Shan-Shan,Jiang ^[1] ; Yi-Le,Xie ^[1] ; Xiu-Ying,Xiao ^[2] ; Zi-Ran,Kang ^[1] ; Xiao-Lin,Lin ^[2] ; Lu,Zhang ^[1] ; Chu-Shu,Li ^[1] ; Yun,Qian ^[1] ; Ping-Ping,Xu ^[1] ; Xiao-Xu,Leng ^[1] ; Li-Wei,Wang ^[2] ; Shui-Ping,Tu ^[2] ; Ming,Zhong ^[3] ; Gang,Zhao ^[3] ; Jin-Xian,Chen ^[3] ; Zheng,Wang ^[3] ; Qiang,Liu ^[4] ; Jie,Hong ^[1] ; Hao-Yan,Chen ^[1] ; Ying-Xuan,Chen ^[5] ; Jing-Yuan,Fang ^[6]

作者单位： Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China. ^[1] Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. ^[2] Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. ^[3] Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. ^[4] Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China. Electronic address: yingxuanchen71@sjtu.edu.cn. ^[5] Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China. Electronic address: jingyuanfang@sjtu.edu.cn. ^[6]

关键词 Fusobacterium nucleatum cGAS-IFN-β pathway colorectal cancer immunotherapy succinic acid