Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.

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第一作者： Cheng,Wang

第一单位： Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.

作者： Cheng,Wang ^[1] ; Gregory C,Adam ^[2] ; Christine,Burlein ^[3] ; Steven,Carroll ^[3] ; William,Dankulich ^[1] ; Tracy,Diamond ^[4] ; Jay,Grobler ^[4] ; Jeffrey,Heath ^[4] ; Adam,Johnson ^[1] ; Daniel,Klein ^[5] ; Daniel,Krosky ^[3] ; Kartik,Narayan ^[3] ; Yangsi,Ou ^[3] ; John,Sanders ^[5] ; Sujata,Sharma ^[2] ; Min,Xu ^[3] ; Antonella,Converso ^[6]

作者单位： Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, USA. ^[1] Screening and Protein Science, Merck & Co., Inc., West Point, PA 19486, USA. ^[2] Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA. ^[3] Infectious Disease Biology Discovery, Merck & Co., Inc., West Point, PA 19486, USA. ^[4] Computational and Structural Chemistry, Merck & Co., Inc., West Point, PA 19486, USA. ^[5] Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, USA. Electronic address: antonella_converso@merck.com. ^[6]

关键词 ALLINIs HIV LEDGF

主题词 HIV整合酶抑制剂(HIV Integrase Inhibitors);别构调节(Allosteric Regulation);抗HIV药(Anti-HIV Agents);催化域(Catalytic Domain);HIV整合酶(HIV Integrase)

DOI 10.1016/j.bmcl.2023.129303

PMID 37146837

发布时间 2023-05-31

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Bioorganic & medicinal chemistry letters

2023年89卷

129303页

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Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.

Bioorganic & medicinal chemistry letters

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Bioorganic & medicinal chemistry letters

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Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.

Bioorganic & medicinal chemistry letters

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Bioorganic & medicinal chemistry letters

相关期刊

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