Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway.

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作者： Yuan-Feng,Zou ^[1] ; Cen-Yu,Li ^[2] ; Yu-Ping,Fu ^[2] ; Xiao-Ping,JiZe ^[2] ; Yu-Zhe,Zhao ^[2] ; Xi,Peng ^[2] ; Jing-Yi,Wang ^[2] ; Zhong-Qiong,Yin ^[2] ; Yang-Ping,Li ^[3] ; Xu,Song ^[2] ; Li-Xia,Li ^[2] ; Xing-Hong,Zhao ^[2] ; Bin,Feng ^[4] ; Chao,Huang ^[5] ; Gang,Ye ^[2] ; Hua-Qiao,Tang ^[2] ; Ji,Chen ^[6] ; Rui,Li ^[6] ; Xing-Fu,Chen ^[7] ; Meng-Liang,Tian ^[8]

作者单位： Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China. ^[1] Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China. ^[2] State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, China College of Agronomy, Sichuan Agricultural University, Chengdu 611130, PR China. ^[3] Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, PR China. ^[4] Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, PR China. ^[5] College of Agronomy, Sichuan Agricultural University, Chengdu 611130, PR China. ^[6] College of Agronomy, Sichuan Agricultural University, Chengdu 611130, PR China. Electronic address: chenxf64@sohu.com. ^[7] College of Agronomy, Sichuan Agricultural University, Chengdu 611130, PR China. Electronic address: secondat@sicau.edu.cn. ^[8]

关键词 5-Methyl-dl-tryptophan Angelica sinensis Colitis Gut microbiota Polysaccharides Serum metabolite