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Model-based assessment of combination therapies - ranking of radiosensitizing agents in oncology.

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第一作者： Marcus,Baaz

第一单位： Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden. Marcus.Baaz@fcc.chalmers.se.;Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. Marcus.Baaz@fcc.chalmers.se.

作者： Marcus,Baaz ^[1] ; Tim,Cardilin ^[2] ; Floriane,Lignet ^[3] ; Astrid,Zimmermann ^[4] ; Samer,El Bawab ^[5] ; Johan,Gabrielsson ^[6] ; Mats,Jirstrand ^[2]

作者单位： Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden. Marcus.Baaz@fcc.chalmers.se.;Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. Marcus.Baaz@fcc.chalmers.se. ^[1] Fraunhofer-Chalmers Research Centre for Industrial Mathematics, Gothenburg, Sweden. ^[2] Translational Medicine, Quantitative Pharmacology, Merck Healthcare KGaA, Darmstadt, Germany. ^[3] Translation Innovation Platform Oncology, Merck Healthcare KGaA, Darmstadt, Germany. ^[4] Translational Medicine, Quantitative Pharmacology, Merck Healthcare KGaA, Darmstadt, Germany.;Present Address: Translational Medicine, Servier, Suresnes, France. ^[5] Meddoor AB, Gothenburg, Sweden. ^[6]

关键词 Combination therapy Inter-study variability Non-linear mixed effects Radiation therapy Tumor static exposure

医学主题词人类(Humans);动物(Animals);小鼠(Mice);辐射增敏药(Radiation-Sensitizing Agents);肿瘤(Neoplasms);抗肿瘤药(Antineoplastic Agents);综合疗法(Combined Modality Therapy)

DOI 10.1186/s12885-023-10899-y

PMID 37149596

发布时间 2023-05-09

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