Reduced pain sensitivity of episodic pain syndrome model mice carrying a Nav1.9 mutation by ANP-230, a novel sodium channel blocker.

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第一作者： Hiroko,Okuda

第一单位： Department of Pain Pharmacogenetics, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.

作者： Hiroko,Okuda ^[1] ; Sumiko,Inoue ^[2] ; Yoshihiro,Oyamada ^[1] ; Akio,Koizumi ^[1] ; Shohab,Youssefian ^[3]

作者单位： Department of Pain Pharmacogenetics, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan. ^[1] Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, 465 Kajiicho Kamigyo-ward, Kyoto, 602-8566, Japan. ^[2] AlphaNavi Pharma Inc., Osaka, 564-0053, Japan. ^[3] Institute of Public Health and Welfare Research, Kyoto, 616-8141, Japan. ^[4] Laboratory of Molecular Biosciences, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan. ^[5]

关键词 Behavioral experiments Electrophysiology Episodic pain syndrome Nav1.9 voltage-gated sodium channel Non-opioid analgesics Pain model mice Pharmacology Sodium channel blocker

DOI 10.1016/j.heliyon.2023.e15423

PMID 37151704

发布时间 2023-05-09

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2023年9卷4期

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Reduced pain sensitivity of episodic pain syndrome model mice carrying a Nav1.9 mutation by ANP-230, a novel sodium channel blocker.

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Reduced pain sensitivity of episodic pain syndrome model mice carrying a Nav1.9 mutation by ANP-230, a novel sodium channel blocker.

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