Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases.

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作者： Matteo,Manca ^[1] ; Heidi G,Standke ^[1] ; Danielle F,Browne ^[1] ; Mikayla L,Huntley ^[1] ; Olivia R,Thomas ^[1] ; Christina D,Orrú ^[2] ; Andrew G,Hughson ^[2] ; Yongya,Kim ^[3] ; Jing,Zhang ^[4] ; Curtis,Tatsuoka ^[5] ; Xiongwei,Zhu ^[1] ; Annie,Hiniker ^[6] ; David G,Coughlin ^[3] ; Douglas,Galasko ^[3] ; Allison,Kraus ^[7]

作者单位： Department of Pathology, Case Western Reserve University School of Medicine, 2103 Cornell Road, Cleveland, OH, 44106, USA. ^[1] Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA. ^[2] Department of Neurosciences, University of California San Diego, San Diego, CA, 92093-0612, USA. ^[3] Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA. ^[4] Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15232, USA. ^[5] Department of Pathology, University of California San Diego, San Diego, CA, 92093-0612, USA. ^[6] Department of Pathology, Case Western Reserve University School of Medicine, 2103 Cornell Road, Cleveland, OH, 44106, USA. allison.kraus@case.edu. ^[7]

关键词 Alpha-synuclein Alzheimer’s disease Protein seeds RT-QuIC Synucleinopathy Tau Tauopathy