Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.

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第一作者： Shun-Qing,Liang

第一单位： RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.

作者： Shun-Qing,Liang ^[1] ; Pengpeng,Liu ^[2] ; Karthikeyan,Ponnienselvan ^[3] ; Sneha,Suresh ^[3] ; Zexiang,Chen ^[1] ; Christian,Kramme ^[4] ; Pranam,Chatterjee ^[5] ; Lihua Julie,Zhu ^[6] ; Erik J,Sontheimer ^[7] ; Wen,Xue ^[8] ; Scot A,Wolfe ^[9]

作者单位： RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. ^[1] Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. Pengpeng.Liu2@umassmed.edu. ^[2] Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. ^[3] Wyss Institute, Harvard Medical School, Boston, MA, USA. ^[4] Wyss Institute, Harvard Medical School, Boston, MA, USA.;Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Biomedical Engineering, Duke University, Durham, NC, USA. ^[5] Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.;Department of Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.;Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. ^[6] RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.;Department of Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.;Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, USA. ^[7] RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. Wen.Xue@umassmed.edu.;Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. Wen.Xue@umassmed.edu.;Department of Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. Wen.Xue@umassmed.edu.;Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, USA. Wen.Xue@umassmed.edu. ^[8] Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. Scot.Wolfe@umassmed.edu.;Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, USA. Scot.Wolfe@umassmed.edu. ^[9]