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Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells.

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作者单位: Surgery Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA. [1] Center of Cell-based Therapy, National Cancer Institute, NIH, Bethesda, MD 20892, USA. [2] Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA. [3] Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. [4] Cellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. [5] Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. [6] Immune Deficiency Genetics Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. [7] Autonomic Medicine Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA. [8] Division of Gastroenterology, Hepatology & Nutrition, Developmental Biology, Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. [9] Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), and Division of Stem Cell and Organoid Medicine, Osaka University, Suita, Osaka 565-0871, Japan. [10] iPSC Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. [11] Cell Processing Section, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, MD 20892, USA. [12] Skeletal Biology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA. [13]
DOI 10.1016/j.crmeth.2023.100460
PMID 37159663
发布时间 2024-05-30
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Cell reports methods

Cell reports methods

2023年3卷4期

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