Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS-induced SIRS model.

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第一作者： Yongjin,Hao

第一单位： Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China.

作者： Yongjin,Hao ^[1] ; Jin,Wang ^[1] ; Jiawan,Ma ^[1] ; Xiaoliang,Yu ^[2] ; Zhanhui,Li ^[1] ; Shuwei,Wu ^[3] ; Sheng,Tian ^[1] ; Haikuo,Ma ^[1] ; Sudan,He ^[4] ; Xiaohu,Zhang ^[5]

作者单位： Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China. ^[1] CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medial College, Beijing, 100005, P. R. China; Suzhou Institute of Systems Medicine, Suzhou, 215123 Jiangsu, P. R. China. ^[2] Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China. Electronic address: swwu@suda.edu.cn. ^[3] CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medial College, Beijing, 100005, P. R. China; Suzhou Institute of Systems Medicine, Suzhou, 215123 Jiangsu, P. R. China; State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, P. R. China. Electronic address: hesd@ism.pumc.edu.cn. ^[4] Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P. R. China. Electronic address: xiaohuzhang@suda.edu.cn. ^[5]

关键词 5-b]pyridine scaffold IRAK4 Inflammation Innate immunity Kinase inhibitor Oxazolo[4 hERG

主题词动物(Animals);小鼠(Mice);细胞因子类(Cytokines);白细胞介素1受体相关激酶类(Interleukin-1 Receptor-Associated Kinases);脂多糖类(Lipopolysaccharides);全身炎症反应综合征(Systemic Inflammatory Response Syndrome);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bioorg.2023.106584

PMID 37163814

发布时间 2023-06-16

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