Retinol-binding protein-hijacking nanopolyplex delivering siRNA to cytoplasm of hepatic stellate cell for liver fibrosis alleviation.

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作者： Jinsheng,Huang ^[1] ; Huiling,Huang ^[2] ; Yiyao,Wang ^[3] ; Bin,Xu ^[3] ; Minzhao,Lin ^[4] ; Shisong,Han ^[5] ; Yuanyuan,Yuan ^[6] ; Yong,Wang ^[7] ; Xintao,Shuai ^[8]

作者单位： Department of Urology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China. Electronic address: huangjsh55@mail.sysu.edu.cn. ^[1] College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China. ^[2] Department of Urology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, China. ^[3] Nanomedicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China; PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, China. ^[4] PCFM Lab of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, China. ^[5] School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: yyy@zcmu.edu.cn. ^[6] College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China. Electronic address: wangy488@jnu.edu.cn. ^[7] Nanomedicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China. Electronic address: shuaixt@mail.sysu.edu.cn. ^[8]

关键词 Biomimetic nanosystem Hepatic stellate cell Liver fibrosis RNA delivery Stimulus-responsive copolymer