Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer.

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第一作者： Natalia A,Kolganova

第一单位： Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

作者： Natalia A,Kolganova ^[1] ; Vladimir B,Tsvetkov ^[2] ; Andrey A,Stomakhin ^[3] ; Sergei A,Surzhikov ^[4] ; Edward N,Timofeev ^[1] ; Irina V,Varizhuk ^[1]

作者单位： Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia. ^[1] Federal Research and Clinical Center of Physical-Chemical Medicine, 119435 Moscow, Russia. ^[2] Institute of Biodesign and Complex System Modeling, Sechenov First Moscow State Medical University, 119146 Moscow, Russia. ^[3] A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991 Moscow, Russia. ^[4]

关键词 G-quadruplex alpha-deoxyguanosine alpha-thrombin anticoagulant activity aptamer circular dichroism molecular dynamics peptide-oligonucleotide conjugate

主题词适体, 核苷(Aptamers, Nucleotide);凝血酶(Thrombin);G四链体(G-Quadruplexes);抗凝药(Anticoagulants);脱氧鸟苷(Deoxyguanosine)

DOI 10.3390/ijms24098406

PMID 37176113

发布时间 2023-05-15

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