Investigation of anti-PF4 versus anti-PF4/heparin reactivity using fluid-phase enzyme immunoassay for 4 anti-PF4 disorders: classic heparin-induced thrombocytopenia (HIT), autoimmune HIT, vaccine-induced immune thrombotic thrombocytopenia, and spontaneous HIT.

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作者： Theodore E,Warkentin ^[1] ; Donald M,Arnold ^[2] ; Jo-Ann I,Sheppard ^[3] ; Jane C,Moore ^[4] ; John G,Kelton ^[2] ; Ishac,Nazy ^[5]

作者单位： Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Service of Benign Hematology, Hamilton Health Sciences, Hamilton, Ontario, Canada; McMaster Centre for Transfusion Research, Hamilton, Ontario, Canada; Hamilton Regional Laboratory Medicine Program, Hamilton, Ontario, Canada. ^[1] Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Service of Benign Hematology, Hamilton Health Sciences, Hamilton, Ontario, Canada; McMaster Centre for Transfusion Research, Hamilton, Ontario, Canada. ^[2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. ^[3] Department of Medicine, McMaster University, Hamilton, Ontario, Canada. ^[4] Department of Medicine, McMaster University, Hamilton, Ontario, Canada; McMaster Centre for Transfusion Research, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. Electronic address: nazyi@mcmaster.ca. ^[5]

关键词 antibodies heparin immunoenzyme techniques platelet factor 4 thrombocytopenia