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Covalent Inhibition by a Natural Product-Inspired Latent Electrophile.

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第一作者： David P,Byun

第一单位： Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.

作者： David P,Byun ^[1] ; Jennifer,Ritchie ^[1] ; Yejin,Jung ^[1] ; Ronald,Holewinski ^[2] ; Hong-Rae,Kim ^[1] ; Ravichandra,Tagirasa ^[1] ; Joseph,Ivanic ^[3] ; Claire M,Weekley ^[4] ; Michael W,Parker ^[5] ; Thorkell,Andresson ^[2] ; Euna,Yoo ^[1]

作者单位： Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States. ^[1] Protein Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biochemical Research, Frederick, Maryland 21702, United States. ^[2] Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, Maryland 21702, United States. ^[3] Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia. ^[4] Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.;Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia. ^[5]

医学主题词人类(Humans);半胱氨酸(Cysteine);生物制品(Biological Products);药物发现(Drug Discovery);丙烯酰胺(Acrylamide);催化域(Catalytic Domain)

DOI 10.1021/jacs.3c00598

PMID 37183434

发布时间 2025-05-30

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