A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer.

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作者： Jeyalakshmi,Kandhavelu ^[1] ; Kumar,Subramanian ^[1] ; Vivash,Naidoo ^[1] ; Giulia,Sebastianelli ^[2] ; Phuong,Doan ^[2] ; Saravanan,Konda Mani ^[3] ; Hande,Yapislar ^[4] ; Ebru,Haciosmanoglu ^[5] ; Leman,Arslan ^[6] ; Samed,Ozer ^[7] ; Ramesh,Thiyagarajan ^[8] ; Nuno R,Candeias ^[6] ; Clement,Penny ^[9] ; Meenakshisundaram,Kandhavelu ^[10] ; Akshaya,Murugesan ^[11]

作者单位： Division of Oncology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. ^[1] Molecular Signalling Lab, Faculty of Medicine and Health Technology, BioMediTech, Tampere University and Tays Cancer Centre, Tampere, Finland. ^[2] BioMediTech Institute and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. ^[3] Science Center, Tampere University Hospital, Tampere, Finland. ^[4] Research and Publication Wing, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India. ^[5] Department of Physiology, Acibadem University School of Medicine, Atasehir, Istanbul, Turkey. ^[6] Department of Biophysics, Bezmialem Vakıf University School of Medicine, Fatih, Istanbul, Turkey. ^[7] Department of Physiology, Bezmialem Vakıf University School of Medicine, Fatih, Istanbul, Turkey. ^[8] Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia. ^[9] LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal. ^[10] Faculty of Engineering and Natural Sciences, Tampere University, Tampere, Finland. ^[11] Department of Biotechnology, Lady Doak College, Thallakulam, Madurai, India. ^[12]

关键词 EGFR inhibitor alkylaminophenols apoptosis colon cancer oncogenesis