Phylogenetic Comparative Analysis of Single-Cell Transcriptomes Reveals Constrained Accumulation of Gene Expression Heterogeneity during Clonal Expansion.

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第一作者： Feng,Chen

第一单位： Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.;Department of Genetics and Biomedical Informatics, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.;Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China.

作者： Feng,Chen ^[1] ; Zizhang,Li ^[2] ; Xiaoyu,Zhang ^[1] ; Peng,Wu ^[2] ; Wenjing,Yang ^[2] ; Junnan,Yang ^[2] ; Xiaoshu,Chen ^[1] ; Jian-Rong,Yang ^[1]

作者单位： Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.;Department of Genetics and Biomedical Informatics, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.;Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China. ^[1] Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. ^[2]

关键词 cell lineage tree functional homeostasis phylogenetic comparative analyses robustness transcriptomic heterogeneity

主题词人类(Humans);种系发生(Phylogeny);HEK293细胞(HEK293 Cells);生物进化(Biological Evolution);基因表达谱(Gene Expression Profiling)

DOI 10.1093/molbev/msad113

PMID 37183780

发布时间 2023-07-02

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