首页> Nature communications> Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes.

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes.

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第一作者： Liam,McAllan

第一单位： Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.;MRC London Institute of Medical Sciences, London, W12 0NN, UK.

作者： Liam,McAllan ^[1] ; Damir,Baranasic ^[1] ; Sergio,Villicaña ^[2] ; Scarlett,Brown ^[1] ; Weihua,Zhang ^[3] ; Benjamin,Lehne ^[4] ; Marco,Adamo ^[5] ; Andrew,Jenkinson ^[5] ; Mohamed,Elkalaawy ^[5] ; Borzoueh,Mohammadi ^[5] ; Majid,Hashemi ^[5] ; Nadia,Fernandes ^[6] ; Nathalie,Lambie ^[6] ; Richard,Williams ^[6] ; Colette,Christiansen ^[7] ; Youwen,Yang ^[8] ; Liudmila,Zudina ^[9] ; Vasiliki,Lagou ^[10] ; Sili,Tan ^[11] ; Juan,Castillo-Fernandez ^[2] ; James W D,King ^[12] ; Richie,Soong ^[13] ; Paul,Elliott ^[14] ; James,Scott ^[15] ; Inga,Prokopenko ^[16] ; Inês,Cebola ^[17] ; Marie,Loh ^[18] ; Boris,Lenhard ^[1] ; Rachel L,Batterham ^[19] ; Jordana T,Bell ^[2] ; John C,Chambers ^[20] ; Jaspal S,Kooner ^[21] ; William R,Scott ^[22]

作者单位： Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.;MRC London Institute of Medical Sciences, London, W12 0NN, UK. ^[1] Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. ^[2] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.;Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK. ^[3] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK. ^[4] UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK. ^[5] Imperial BRC Genomics Facility, Faculty of Medicine, Imperial College London, London, W12 0NN, UK. ^[6] Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.;School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, UK. ^[7] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.;School of Cardiovascular and Metabolic Medicine and Sciences, James Black Centre, King's College London British Heart Foundation Centre of Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK. ^[8] Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK. ^[9] Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.;VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium. ^[10] Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. ^[11] MRC London Institute of Medical Sciences, London, W12 0NN, UK. ^[12] Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.;Department of Pathology, National University Hospital, Singapore, Singapore. ^[13] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.;MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.;National Institute for Health Research Biomedical Research Centre, Imperial College London, London, UK. ^[14] National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.;Imperial College Healthcare NHS Trust, London, W12 0HS, UK. ^[15] Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK.;People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.;Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation. ^[16] Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. ^[17] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.;Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore.;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. ^[18] UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK.;Centre for Obesity Research, Rayne Institute, Department of Medicine, University College, London, WC1E 6JJ, UK.;National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, W1T 7DN, UK. ^[19] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.;Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.;MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.;Imperial College Healthcare NHS Trust, London, W12 0HS, UK.;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. ^[20] Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.;MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.;National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.;Imperial College Healthcare NHS Trust, London, W12 0HS, UK. ^[21] Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK. w.scott@imperial.ac.uk.;MRC London Institute of Medical Sciences, London, W12 0NN, UK. w.scott@imperial.ac.uk.;Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK. w.scott@imperial.ac.uk.;Imperial College Healthcare NHS Trust, London, W12 0HS, UK. w.scott@imperial.ac.uk. ^[22]