SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer.

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第一作者： Yin Quan,Zhao

第一单位： Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin Province, China.;School of Life Sciences, Jilin University, Changchun, Jilin Province, China.;Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

作者： Yin Quan,Zhao ^[1] ; Hong Ri,Jin ^[2] ; Daeho,Kim ^[2] ; Sung Han,Jung ^[2] ; Sheng,Liu ^[3] ; Jun,Wan ^[3] ; Ho-Yin,Lo ^[4] ; Xue Qi,Fu ^[5] ; Quan,Wang ^[6] ; Chunhai,Hao ^[2] ; Anita C,Bellail ^[7]

作者单位： Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin Province, China.;School of Life Sciences, Jilin University, Changchun, Jilin Province, China.;Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA. ^[1] Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA. ^[2] Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA. ^[3] Synovel Laboratory LLC, Danbury, Connecticut, USA. ^[4] School of Life Sciences, Jilin University, Changchun, Jilin Province, China. ^[5] Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin Province, China. ^[6] Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.;HB Therapeutics Inc., Indianapolis, Indiana, USA. ^[7]

关键词 ER stress SUMO1 degrader StarD7 TCF4 colon cancer

主题词人类(Humans);载体蛋白质类(Carrier Proteins);活性氧(Reactive Oxygen Species);结肠肿瘤(Colonic Neoplasms);RNA, 信使(RNA, Messenger);SUMO1蛋白(SUMO-1 Protein)

DOI 10.1002/mc.23560

PMID 37191369

发布时间 2024-02-10

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