Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy.

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第一作者： Yi-Qian,Li

第一单位： Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.;Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.

作者： Yi-Qian,Li ^[1] ; William G,Lannigan ^[2] ; Shabnam,Davoodi ^[1] ; Fereidoon,Daryaee ^[1] ; Ana,Corrionero ^[3] ; Patricia,Alfonso ^[3] ; Jose A,Rodriguez-Santamaria ^[3] ; Nan,Wang ^[1] ; John D,Haley ^[4] ; Peter J,Tonge ^[5]

作者单位： Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.;Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States. ^[1] Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States. ^[2] Enzymlogic S.L., QUBE Technology Park, C/ Santiago Grisolía, 2, Madrid 28760, Spain. ^[3] Department of Pathology, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-8691, United States. ^[4] Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.;Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.;Department of Radiology, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States. ^[5]

主题词人类(Humans);B-淋巴细胞(B-Lymphocytes);细胞增殖(Cell Proliferation);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases)

DOI 10.1021/acs.jmedchem.3c00176

PMID 37195170

发布时间 2024-06-09

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