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Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease.

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作者: European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration [1] ; Jiao,Luo [1] ; Jesper Qvist,Thomassen [2] ; Céline,Bellenguez [2] ; Benjamin,Grenier-Boley [3] ; Itziar,de Rojas [4] ; Atahualpa,Castillo [5] ; Kayenat,Parveen [6] ; Fahri,Küçükali [7] ; Aude,Nicolas [8] ; Oliver,Peters [9] ; Anja,Schneider [2] ; Martin,Dichgans [10] ; Dan,Rujescu [11] ; Norbert,Scherbaum [12] ; Deckert,Jürgen [13] ; Steffi,Riedel-Heller [14] ; Lucrezia,Hausner [15] ; Laura Molina,Porcel [16] ; Emrah,Düzel [17] ; Timo,Grimmer [18] ; Jens,Wiltfang [19] ; Stefanie,Heilmann-Heimbach [20] ; Susanne,Moebus [21] ; Thomas,Tegos [22] ; Nikolaos,Scarmeas [23] ; Jordi,Clarimon [24] ; Fermin,Moreno [25] ; Jordi,Pérez-Tur [26] ; María J,Bullido [27] ; Pau,Pastor [28] ; Raquel,Sánchez-Valle [29] ; Victoria,Álvarez [30] ; Mercè,Boada [31] ; Pablo,García-González [32] ; Raquel,Puerta [33] ; Pablo,Mir [34] ; Luis M,Real [35] ; Gerard,Piñol-Ripoll [4] ; Jose María,García-Alberca [36] ; Jose Luís,Royo [4] ; Eloy,Rodriguez-Rodriguez [37] ; Hilkka,Soininen [38] ; Teemu,Kuulasmaa [4] ; Alexandre,de Mendonça [39] ; Shima,Mehrabian [40] ; Jakub,Hort [4] ; Martin,Vyhnalek [41] ; Sven,van der Lee [42] ; Caroline,Graff [43] ; Goran,Papenberg [44] ; Vilmantas,Giedraitis [45] ; Anne,Boland [46] ; Delphine,Bacq-Daian [3] ; Jean-François,Deleuze [4] ; Gael,Nicolas [3] ; Carole,Dufouil [3] ; Florence,Pasquier [4] ; Olivier,Hanon [47] ; Stéphanie,Debette [48] ; Edna,Grünblatt [49] ; Julius,Popp [50] ; Luisa,Benussi [51] ; Daniela,Galimberti [4] ; Beatrice,Arosio [52] ; Patrizia,Mecocci [49] ; Vincenzo,Solfrizzi [4] ; Lucilla,Parnetti [53] ; Alessio,Squassina [54] ; Lucio,Tremolizzo [55] ; Barbara,Borroni [56] ; Benedetta,Nacmias [57] ; Sandro,Sorbi [58] ; Paolo,Caffarra [59] ; Davide,Seripa [58] ; Innocenzo,Rainero [59] ; Antonio,Daniele [60] ; Carlo,Masullo [61] ; Gianfranco,Spalletta [62] ; Julie,Williams [63] ; Philippe,Amouyel [64] ; Frank,Jessen [65] ; Patrick,Kehoe [66] ; Magda,Tsolaki [66] ; Giacomina,Rossi [66] ; Pascual,Sánchez-Juan [67] ; Kristel,Sleegers [68] ; Martin,Ingelsson [69] ; Ole A,Andreassen [70] ; Mikko,Hiltunen [71] ; Cornelia,Van Duijn [72] ; Rebecca,Sims [73] ; Wiesje,van der Flier [74] ; Agustín,Ruiz [75] ; Alfredo,Ramirez [76] ; Jean-Charles,Lambert [77] ; Ruth,Frikke-Schmidt [78]
作者单位: Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. [1] Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE-Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. [2] Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain. [3] Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain. [4] Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, United Kingdom. [5] Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. [6] Department of Neurodegenerative diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany. [7] Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, Antwerp, Belgium. [8] Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. [9] German Center for Neurodegenerative Diseases, Berlin, Germany. [10] Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Berlin, Germany. [11] German Center for Neurodegenerative Diseases, Bonn, Germany. [12] Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany. [13] Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany. [14] German Center for Neurodegenerative Diseases, Munich, Germany. [15] Munich Cluster for Systems Neurology, Munich, Germany. [16] Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. [17] Comprehensive Centre for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria. [18] LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany. [19] Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany. [20] Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany. [21] Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. [22] Neurological Tissue Bank, Biobanc Hospital Clinic, Instituto de Investigaciones Biomédicas August Pi i Sunyer, Barcelona, Spain. [23] Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain. [24] German Center for Neurodegenerative Diseases, Magdeburg, Germany. [25] Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany. [26] Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Munich, Germany. [27] Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany. [28] German Center for Neurodegenerative Diseases, Goettingen, Germany. [29] Medical Science Department, Instituto de Biomedicina, Aveiro, Portugal. [30] Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany. [31] Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany. [32] First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. [33] First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece. [34] Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York. [35] Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. [36] Department of Neurology, Hospital Universitario Donostia, San Sebastian, Spain. [37] Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain. [38] Unitat de Genètica Molecular, Institut de Biomedicina de València, Consejo Superior de Investigaciones Científicas, Valencia, Spain. [39] Unidad Mixta de Neurologia Genètica, Instituto de Investigación Sanitaria La Fe, Valencia, Spain. [40] Centro de Biología Molecular Severo Ochoa, UAM-CSIC, Madrid, Spain. [41] Instituto de Investigacion Sanitaria Hospital la Paz, Madrid, Spain. [42] Unit of Neurodegenerative Diseases, Department of Neurology, University Hospital Germans Trias i Pujol and The Germans Trias i Pujol Research Institute (IGTP) Badalona, Barcelona, Spain. [43] Alzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. [44] Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain. [45] Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain. [46] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Seville, Spain. [47] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain. [48] Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain. [49] Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain. [50] Institut de Recerca Biomedica de Lleida, Lleida, Spain. [51] Alzheimer Research Center & Memory Clinic, Instituto Andaluz de Neurociencia, Málaga, Spain. [52] Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria and IDIVAL, Santander, Spain. [53] Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland. [54] Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. [55] Faculty of Medicine, University of Lisbon, Portugal. [56] Clinic of Neurology, UH "Alexandrovska," Medical University-Sofia, Sofia, Bulgaria. [57] Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic. [58] International Clinical Research Center, St Anne's University Hospital Brno, Brno, Czech Republic. [59] Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, locatie VUmc, Amsterdam, the Netherlands. [60] Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, locatie VUmc, Amsterdam, the Netherlands. [61] Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands. [62] Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital-Solna, Stockholm, Sweden. [63] Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. [64] Department of Public Health and Caring Sciences/ and Geriatrics, Uppsala University, Uppsala, Sweden. [65] Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France. [66] Normandie Univ, Université de Rouen Normandie, Inserm U1245 and CHU Rouen, Department of Genetics and Centre national de référence pour les malades Alzheimer jeunes, Rouen, France. [67] Inserm, Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, ISPED, CIC 1401-EC, Bordeaux, France. [68] CHU de Bordeaux, Pole santé publique, Bordeaux, France. [69] University of Lille, Inserm, CHU Lille, UMR1172, Resources and Research Memory Center of Distalz, Licend, Lille, France. [70] Université de Paris, EA 4468, Assistance Publique - Hôpitaux de Paris, Hôpital Broca, Paris, France. [71] University Bordeaux, Inserm, Bordeaux Population Health Research Center, France. [72] Department of Neurology, Bordeaux University Hospital, Bordeaux, France. [73] Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland. [74] Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland. [75] Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. [76] Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland. [77] Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland. [78] Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Zurich, Switzerland. [79] Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. [80] Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy. [81] Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. [82] Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. [83] Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. [84] Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy. [85] Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. [86] Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari Aldo Moro, Bari, Italy. [87] Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy. [88] Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy. [89] Neurology Unit, Hospital San Gerardo, Monza and University of Milano-Bicocca, Milan, Italy. [90] Centre for Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. [91] Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy. [92] IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy. [93] Unit of Neurology, University of Parma, Parma, Italy. [94] Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy. [95] Department of Neuroscience Rita Levi Montalcini, University of Torino, Torino, Italy. [96] Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy. [97] Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy. [98] Institute of Neurology, Università Cattolica del Sacro Cuore, Rome, Italy. [99] Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy. [100] Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas. [101] UK Dementia Research Institute at Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom. [102] Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany. [103] Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. [104] Unit of Neurology V - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. [105] Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Madrid, Spain. [106] Krembil Brain Institute, University Health Network, Toronto, Canada. [107] Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada. [108] NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. [109] Institute of Clinical Medicine, University of Oslo, Oslo, Norway. [110] Department of Epidemiology, ErasmusMC, Rotterdam, the Netherlands. [111] Nuffield Department of Population Health, Oxford University, Oxford, United Kingdom. [112] Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, Texas. [113] Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. [114]
DOI 10.1001/jamanetworkopen.2023.13734
PMID 37195665
发布时间 2024-06-26
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