Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers.

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作者： Katia E,Maalouf ^[1] ; Christine A,Vaine ^[1] ; Dawn M,Frederick ^[2] ; Akiko,Yoshinaga ^[2] ; Wataru,Obuchi ^[2] ; Shadi,Mahjoum ^[2] ; Lisa,Nieland ^[2] ; Jamal,Al Ali ^[2] ; D Cristopher,Bragg ^[1] ; Xandra O,Breakefield ^[3] ; Koen,Breyne ^[4]

作者单位： Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; The Collaborative Center for X-linked Dystonia-Parkinsonism, Massachusetts General Hospital, Charlestown, MA 02129, USA. ^[1] Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ^[2] Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; The Collaborative Center for X-linked Dystonia-Parkinsonism, Massachusetts General Hospital, Charlestown, MA 02129, USA; Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA. Electronic address: breakefield@hms.harvard.edu. ^[3] Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA. Electronic address: kbreyne@mgh.harvard.edu. ^[4]

关键词 Extracellular vesicles TAF1-32i X-linked dystonia-parkinsonism biomarkers brain human iPSC-derived neural progenitor cells neurologic disease xenograft model

主题词人类(Humans);小鼠(Mice);动物(Animals);神经变性疾病(Neurodegenerative Diseases);转录因子TFIID(Transcription Factor TFIID);脑(Brain)

DOI 10.1016/j.ymthe.2023.05.011

PMID 37198883

发布时间 2024-07-06

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