Design, synthesis, and pharmacological evaluation of N-(3-carbamoyl-1H-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as interleukin-1 receptor-associated kinase 4 inhibitors with reduced potential for cytochrome P450 1A2 induction.

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第一作者： Hiroshi,Inami

第一单位： Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan. Electronic address: hiroshi.inami@astellas.com.

作者： Hiroshi,Inami ^[1] ; Tsuyoshi,Mizutani ^[2] ; Junko,Watanabe ^[2] ; Hisashi,Hayashida ^[2] ; Tomonori,Ito ^[2] ; Takeshi,Terasawa ^[2] ; Toru,Kontani ^[2] ; Hiroaki,Yamagishi ^[2] ; Hiroyuki,Usuda ^[2] ; Naohiro,Aoyama ^[2] ; Emiko,Imamura ^[2] ; Takeshi,Ishikawa ^[2]

作者单位： Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan. Electronic address: hiroshi.inami@astellas.com. ^[1] Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan. ^[2]

关键词 AS2444697 Cytochrome P450 1A2 induction Cytochrome P450 inhibition Interleukin-1 receptor-associated kinase 4 inhibitor Oral bioavailability

主题词抗惊厥药(Anticonvulsants);细胞色素P450 CYP1A2(Cytochrome P-450 CYP1A2);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);白细胞介素1受体相关激酶类(Interleukin-1 Receptor-Associated Kinases);恶唑类(Oxazoles);吡唑类(Pyrazoles);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmc.2023.117302

PMID 37201454

发布时间 2024-01-23

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