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Radiogenomic profiling of prostate tumors prior to external beam radiotherapy converges on a transcriptomic signature of TGF-β activity driving tumor recurrence.

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第一作者： Anson T,Ku

第一单位： Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, MD, USA.

作者： Anson T,Ku ^[1] ; Uma,Shankavaram ^[2] ; Shana Y,Trostel ^[1] ; Hong,Zhang ^[2] ; Houssein A,Sater ^[3] ; Stephanie A,Harmon ^[4] ; Nicole V,Carrabba ^[1] ; Yang,Liu ^[5] ; Bradford J,Wood ^[6] ; Peter A,Pinto ^[7] ; Peter L,Choyke ^[4] ; Radka,Stoyanova ^[8] ; Elai,Davicioni ^[5] ; Alan,Pollack ^[8] ; Baris,Turkbey ^[4] ; Adam G,Sowalsky ^[1] ; Deborah E,Citrin ^[2]

作者单位： Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, MD, USA. ^[1] Radiation Oncology Branch, National Cancer Institute, Bethesda, MD, USA. ^[2] Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA. ^[3] Molecular Imaging Branch, National Cancer Institute, Bethesda, MD, USA. ^[4] Veracyte, Inc., South San Francisco, CA, USA. ^[5] Center for Interventional Oncology, NIH Clinical Center, Bethesda, MD, USA. ^[6] Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, USA. ^[7] Department of Radiation Oncology, University of Miami, Miami, FL, USA. ^[8]

关键词 genomics multiparametric MRI prostate cancer radiotherapy transcriptomics

DOI 10.1101/2023.05.01.23288883

PMID 37205576

发布时间 2025-12-15

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Radiogenomic profiling of prostate tumors prior to external beam radiotherapy converges on a transcriptomic signature of TGF-β activity driving tumor recurrence.

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Radiogenomic profiling of prostate tumors prior to external beam radiotherapy converges on a transcriptomic signature of TGF-β activity driving tumor recurrence.

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