Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma.

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第一作者： Alexandra,Lahtinen

第一单位： Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

作者： Alexandra,Lahtinen ^[1] ; Kari,Lavikka ^[1] ; Anni,Virtanen ^[2] ; Yilin,Li ^[1] ; Sanaz,Jamalzadeh ^[1] ; Aikaterini,Skorda ^[3] ; Anna Røssberg,Lauridsen ^[3] ; Kaiyang,Zhang ^[1] ; Giovanni,Marchi ^[1] ; Veli-Matti,Isoviita ^[1] ; Valeria,Ariotta ^[1] ; Oskari,Lehtonen ^[1] ; Taru A,Muranen ^[1] ; Kaisa,Huhtinen ^[4] ; Olli,Carpén ^[5] ; Sakari,Hietanen ^[6] ; Wojciech,Senkowski ^[7] ; Tuula,Kallunki ^[8] ; Antti,Häkkinen ^[1] ; Johanna,Hynninen ^[6] ; Jaana,Oikkonen ^[9] ; Sampsa,Hautaniemi ^[10]

作者单位： Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland. ^[1] Department of Pathology, University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital, 00029 Helsinki, Finland. ^[2] Cancer Invasion and Resistance Group, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark. ^[3] Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland; Cancer Research Unit, Institute of Biomedicine and FICAN West Cancer Centre, University of Turku, 20014 Turku, Finland. ^[4] Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland; Department of Pathology, University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital, 00029 Helsinki, Finland. ^[5] Department of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, 200521 Turku, Finland. ^[6] Biotech Research and Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark. ^[7] Cancer Invasion and Resistance Group, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. ^[8] Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland. Electronic address: jaana.oikkonen@helsinki.fi. ^[9] Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland. Electronic address: sampsa.hautaniemi@helsinki.fi. ^[10]

关键词 Cancer Evolutionary trajectories Integrative analysis Multiregion sampling Organoid experiments Ovarian cancer PI3K/AKT Prospective cohort Tumor evolution Tumor heterogeneity

主题词女(雌)性(Female);人类(Humans);卵巢肿瘤(Ovarian Neoplasms);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);前瞻性研究(Prospective Studies);囊腺癌, 浆液(Cystadenocarcinoma, Serous);输卵管肿瘤(Fallopian Tube Neoplasms)

DOI 10.1016/j.ccell.2023.04.017

PMID 37207655

发布时间 2023-06-22

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