The feedback loop of AURKA/DDX5/TMEM147-AS1/let-7 drives lipophagy to induce cisplatin resistance in epithelial ovarian cancer.

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第一作者： Yang,Shao

第一单位： Cancer Institute, Fudan University Shanghai Cancer Center and Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

作者： Yang,Shao ^[1] ; Hui,Li ^[2] ; Yong,Wu ^[3] ; XianYi,Wang ^[4] ; Jiao,Meng ^[1] ; ZhiXiang,Hu ^[5] ; LingFang,Xia ^[6] ; SiYu,Cao ^[6] ; WenJuan,Tian ^[6] ; YunKui,Zhang ^[7] ; Xu,Feng ^[8] ; XiaoFan,Zhang ^[9] ; YanLi,Li ^[10] ; Gong,Yang ^[11]

作者单位： Cancer Institute, Fudan University Shanghai Cancer Center and Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. ^[1] Cancer Institute, Fudan University Shanghai Cancer Center and Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China; Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. ^[2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China; Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. ^[3] Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai, 200444, China. ^[4] Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. ^[5] Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. ^[6] Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. ^[7] Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. ^[8] Shanghai Collaborative Innovation Center of Agri-Seeds, Joint Center for Single Cell Biology, School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. Electronic address: zhangxf2021@sjtu.edu.cn. ^[9] Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai, 200444, China. Electronic address: liyanli@shu.edu.cn. ^[10] Cancer Institute, Fudan University Shanghai Cancer Center and Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address: yanggong@fudan.edu.cn. ^[11]

关键词 AURKA/DDX5 Cisplatin resistance Epithelial ovarian cancer Lipophagy TMEM147-AS1