Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex.

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作者： Renuka,Kandhaya-Pillai ^[1] ; Francesc,Miro-Mur ^[2] ; Jaume,Alijotas-Reig ^[3] ; Tamar,Tchkonia ^[2] ; Simo,Schwartz ^[2] ; James L,Kirkland ^[3] ; Junko,Oshima ^[4]

作者单位： Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA. ^[1] Systemic Autoimmune Diseases Research Unit, Vall d&#x2019;Hebron Research Institute (VHIR), Barcelona 08035, Spain. ^[2] Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA. ^[3] Department of Physiology, Mayo Clinic, Rochester, MN 55905, USA. ^[4] Drug Delivery and Targeting Group, Clinical Biochemistry Department, Vall d&#x2019;Hebron Hospital, Barcelona 08035, Spain. ^[5] Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA. ^[6]

关键词 DNA repair DREAM complex cell cycle cellular senescence

主题词肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);染色质(Chromatin);DNA修复(DNA Repair)

DOI 10.18632/aging.204743

PMID 37219418

发布时间 2024-02-07

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