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Multimodal analysis of genome-wide methylation, copy number aberrations, and end motif signatures enhances detection of early-stage breast cancer.

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第一作者： Thi Mong Quynh,Pham

第一单位： Medical Genetics Institute, Ho Chi Minh, Vietnam.;Research and Development Department Gene Solutions, Ho Chi Minh, Vietnam.

作者： Thi Mong Quynh,Pham ^[1] ; Thanh Hai,Phan ^[2] ; Thanh Xuan,Jasmine ^[2] ; Thuy Thi Thu,Tran ^[1] ; Le Anh Khoa,Huynh ^[3] ; Thi Loan,Vo ^[2] ; Thi Huong Thoang,Nai ^[2] ; Thuy Trang,Tran ^[2] ; My Hoang,Truong ^[2] ; Ngan Chau,Tran ^[2] ; Van Thien Chi,Nguyen ^[1] ; Trong Hieu,Nguyen ^[1] ; Thi Hue Hanh,Nguyen ^[1] ; Nguyen Duy Khang,Le ^[1] ; Thanh Dat,Nguyen ^[1] ; Duy Sinh,Nguyen ^[4] ; Dinh Kiet,Truong ^[5] ; Thi Thanh Thuy,Do ^[5] ; Minh-Duy,Phan ^[1] ; Hoa,Giang ^[1] ; Hoai-Nghia,Nguyen ^[1] ; Le Son,Tran ^[1]

作者单位： Medical Genetics Institute, Ho Chi Minh, Vietnam.;Research and Development Department Gene Solutions, Ho Chi Minh, Vietnam. ^[1] Ultrasound Department Medic Medical Center, Ho Chi Minh, Vietnam. ^[2] Medical Genetics Institute, Ho Chi Minh, Vietnam.;Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States. ^[3] Research and Development Department Gene Solutions, Ho Chi Minh, Vietnam.;Faculty of Medicine Nguyen Tat Thanh University, Ho Chi Minh, Vietnam. ^[4] Medical Genetics Institute, Ho Chi Minh, Vietnam. ^[5]

关键词 SPOT-MAS (Screen for the Presence Of Tumor by DNA Methylation And Size)breast cancer early detection cfDNA (circulating cell-free DNA)copy number aberration (CNA)ctDNA (circulating tumor DNA)end motif machine learning model whole genome methylation

DOI 10.3389/fonc.2023.1127086

PMID 37223690

发布时间 2023-05-25

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