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A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses.

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作者单位: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. [1] IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92307, USA.;Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92307, USA.;Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92307, USA. [2] Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA. [3] IAVI, 125 Broad Street, 9th Floor, New York, NY 10004, USA. [4] Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.;Department of Medicine, University of Washington, Seattle, WA 98195, USA. [5] Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, Washington DC, 20052, USA.;Department of Medicine, School of Medicine and Health Sciences, George Washington University, Washington DC 20052, USA. [6] Department of Radiology, University of Washington, Seattle, WA 98195, USA. [7] Department of Radiology, School of Medicine and Health Sciences, George Washington University, Washington DC 20052, USA. [8] Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, Washington DC, 20052, USA. [9] IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92307, USA.;Center for HIV/AIDS Vaccine Development, Scripps Research Institute, La Jolla, CA 92307, USA.;Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92307, USA.;Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. [10]
DOI 10.1126/scitranslmed.adf3309
PMID 37224227
发布时间 2024-12-07
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