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Eculizumab treatment alters the proteometabolome beyond the inhibition of complement.

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第一作者： Christopher,Nelke

第一单位： Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

作者： Christopher,Nelke ^[1] ; Christina B,Schroeter ^[1] ; Frauke,Stascheit ^[2] ; Niklas,Huntemann ^[1] ; Marc,Pawlitzki ^[1] ; Alice,Willison ^[1] ; Saskia,Räuber ^[1] ; Nico,Melzer ^[1] ; Ute,Distler ^[3] ; Stefan,Tenzer ^[4] ; Kai,Stühler ^[5] ; Andreas,Roos ^[6] ; Andreas,Meisel ^[7] ; Sven G,Meuth ^[1] ; Tobias,Ruck ^[1]

作者单位： Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. ^[1] Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Neurology and Experimental Neurology, Berlin, Germany.;Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Neuroscience Clinical Research Center, Berlin, Germany. ^[2] University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany. ^[3] University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany.;Helmholtz Institute for Translational Oncology (HI-TRON) Mainz, Germany.;Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. ^[4] Molecular Proteomics Laboratory, Heinrich Heine University, Düsseldorf, Germany. ^[5] Department of Neuropediatrics, University of Duisburg-Essen, Essen, Germany. ^[6] Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Neurology and Experimental Neurology, Berlin, Germany.;Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Neuroscience Clinical Research Center, Berlin, Germany.;Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Center for Stroke Research Berlin, Berlin, Germany. ^[7]

关键词 Autoimmune diseases Autoimmunity Complement Neuromuscular disease Neuroscience

医学主题词人类(Humans);补体C5(Complement C5);补体系统蛋白质类(Complement System Proteins);补体激活(Complement Activation);重症肌无力(Myasthenia Gravis);受体, 过敏毒素C5a(Receptor, Anaphylatoxin C5a);白三烯类(Leukotrienes)

DOI 10.1172/jci.insight.169135

PMID 37227781

发布时间 2024-09-22

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