首页> Molecular omics> Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer.

Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer.

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第一作者： Daigo,Gunji

第一单位： Laboratory of Proteome Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan. jun_adachi@nibiohn.go.jp.;Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan.;Department of Surgery, Kyoto University Graduate School of Medicine Faculty of Medicine, Kyoto, 606-8507, Japan.

作者： Daigo,Gunji ^[1] ; Ryohei,Narumi ^[2] ; Satoshi,Muraoka ^[3] ; Junko,Isoyama ^[2] ; Narumi,Ikemoto ^[2] ; Mimiko,Ishida ^[2] ; Takeshi,Tomonaga ^[2] ; Yoshiharu,Sakai ^[4] ; Kazutaka,Obama ^[4] ; Jun,Adachi ^[5]

作者单位： Laboratory of Proteome Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan. jun_adachi@nibiohn.go.jp.;Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan.;Department of Surgery, Kyoto University Graduate School of Medicine Faculty of Medicine, Kyoto, 606-8507, Japan. ^[1] Laboratory of Proteome Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan. jun_adachi@nibiohn.go.jp.;Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan. ^[2] Laboratory of Proteome Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan. jun_adachi@nibiohn.go.jp.;Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan.;Laboratory of Clinical and Analytical Chemistry, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan. ^[3] Department of Surgery, Kyoto University Graduate School of Medicine Faculty of Medicine, Kyoto, 606-8507, Japan. ^[4] Laboratory of Proteome Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan. jun_adachi@nibiohn.go.jp.;Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan.;Laboratory of Clinical and Analytical Chemistry, Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan.;Laboratory of Proteomics and Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan. ^[5]

医学主题词人类(Humans);衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);细胞周期蛋白质类(Cell Cycle Proteins);细胞系, 肿瘤(Cell Line, Tumor);结直肠肿瘤(Colorectal Neoplasms);突变(Mutation);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));信号传导(Signal Transduction)

DOI 10.1039/d3mo00042g

PMID 37232035

发布时间 2023-10-03

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Molecular omics

2023年19卷8期

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Molecular omics

2023年19卷8期

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Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer.

Molecular omics

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Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer.

Molecular omics

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Molecular omics

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