Unwinding mechanism of SARS-CoV helicase (nsp13) in the presence of Ca<sup>2+</sup>, elucidated by biochemical and single-molecular studies.
第一作者:
Jeongmin,Yu
第一单位:
School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea.
作者:
主题词
钙(Calcium);DNA(DNA);镁(Magnesium);核酸构象(Nucleic Acid Conformation);腺苷三磷酸(Adenosine Triphosphate);病毒复制(Virus Replication);胞质溶胶(Cytosol);水解作用(Hydrolysis);RNA解螺旋酶类(RNA Helicases);病毒非结构蛋白质类(Viral Nonstructural Proteins);荧光共振能量转移(Fluorescence Resonance Energy Transfer);电泳, 聚丙烯酰氨凝胶(Electrophoresis, Polyacrylamide Gel);剂量效应关系, 药物(Dose-Response Relationship, Drug);转录, 遗传(Transcription, Genetic)
DOI
10.1016/j.bbrc.2023.05.062
PMID
37235917
发布时间
2025-08-01
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