Differential Methylation of Telomere-Related Genes Is Associated with Kidney Disease in Individuals with Type 1 Diabetes.

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第一作者： Claire,Hill

第一单位： Centre for Public Health, Queen's University of Belfast, Belfast BT12 6BA, UK.

作者： Claire,Hill ^[1] ; Seamus,Duffy ^[1] ; Laura M,Kettyle ^[2] ; Liane,McGlynn ^[3] ; Niina,Sandholm ^[4] ; Rany M,Salem ^[5] ; Alex,Thompson ^[6] ; Elizabeth J,Swan ^[7] ; Jill,Kilner ^[8] ; Peter,Rossing ^[1] ; Paul G,Shiels ^[1] ; Maria,Lajer ^[9] ; Per-Henrik,Groop ^[10] ; Alexander Peter,Maxwell ^[11] ; Amy Jayne,McKnight ^[12] ; On Behalf Of The Genie Consortium ^[10]

作者单位： Centre for Public Health, Queen's University of Belfast, Belfast BT12 6BA, UK. ^[1] Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast BT9 7AE, UK. ^[2] College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. ^[3] Folkhälsan Institute of Genetics, Folkhälsan Research Center, 00290 Helsinki, Finland. ^[4] Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, 00290 Helsinki, Finland. ^[5] Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland. ^[6] Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA 92093, USA. ^[7] School of Medicine, The Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK. ^[8] Nordsjaellands Hospital, Hilleroed, Denmark and Health, Aarhus University, 8000 Aarhus, Denmark. ^[9] Steno Diabetes Center, 2730 Gentofte, Denmark. ^[10] Department of Clinical Medicine, University of Copenhagen, 1165 Copenhagen, Denmark. ^[11] School of Molecular Biosciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK. ^[12] Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3800, Australia. ^[13] Regional Nephrology Unit, Belfast City Hospital, Belfast BT9 7AB, UK. ^[14]

关键词 SNP biological ageing diabetic kidney disease epigenetic genetic methylation telomere

主题词人类(Humans);老年人(Aged);糖尿病, 1型(Diabetes Mellitus, Type 1);糖尿病肾病(Diabetic Nephropathies);肾功能衰竭, 慢性(Kidney Failure, Chronic);DNA甲基化(DNA Methylation);端粒(Telomere)

DOI 10.3390/genes14051029

PMID 37239390

发布时间 2023-05-31

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