首页> International journal of molecular sciences> Xenon's Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice.

Xenon's Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice.

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第一作者： Nour El Dine,Kassab

第一单位： Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.

作者： Nour El Dine,Kassab ^[1] ; Verena,Mehlfeld ^[2] ; Jennifer,Kass ^[2] ; Martin,Biel ^[2] ; Gerhard,Schneider ^[1] ; Gerhard,Rammes ^[1]

作者单位： Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany. ^[1] Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany. ^[2]

关键词 anesthesia cyclic adenosine monophosphate (cAMP)cyclic nucleotide-binding domain (CNBD)electrophysiology hyperpolarization-activated cyclic nucleotide-gated type-2 (HCN2)knocked-in hyperpolarization-activated cyclic nucleotide-gated type-2 mouse model ventrobasal thalamus (VB)xenon