Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy.

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作者： Nikolas T,Martin ^[1] ; Mathieu J F,Crupi ^[2] ; Zaid,Taha ^[1] ; Joanna,Poutou ^[2] ; Jack T,Whelan ^[1] ; Sydney,Vallati ^[2] ; Julia,Petryk ^[1] ; Ricardo,Marius ^[2] ; Bradley,Austin ^[1] ; Taha,Azad ^[2] ; Mason,Boulanger ^[1] ; Tamara,Burgess ^[2] ; Ilson,Sanders ^[1] ; Camille,Victoor ^[1] ; Bryan C,Dickinson ^[1] ; Jean-Simon,Diallo ^[1] ; Carolina S,Ilkow ^[2] ; John C,Bell ^[1]

作者单位： Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. ^[1] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[2] Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA. ^[3]

关键词 Split-T7 RNA polymerase chlorotoxin interleukin-12 oncolytic vaccinia virus

DOI 10.3390/ph16050709

PMID 37242495

发布时间 2024-03-28

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