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Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models.

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第一作者： María M,Lorenzo

第一单位： Departamento de Biotecnología, INIA CSIC, Carretera La Coruña km 7.5, E-28040 Madrid, Spain.

作者： María M,Lorenzo ^[1] ; Alejandro,Marín-López ^[2] ; Kevin,Chiem ^[3] ; Luis,Jimenez-Cabello ^[4] ; Irfan,Ullah ^[2] ; Sergio,Utrilla-Trigo ^[4] ; Eva,Calvo-Pinilla ^[4] ; Gema,Lorenzo ^[4] ; Sandra,Moreno ^[5] ; Chengjin,Ye ^[3] ; Jun-Gyu,Park ^[3] ; Alejandro,Matía ^[1] ; Alejandro,Brun ^[4] ; Juana M,Sánchez-Puig ^[1] ; Aitor,Nogales ^[4] ; Walther,Mothes ^[6] ; Pradeep D,Uchil ^[6] ; Priti,Kumar ^[3] ; Javier,Ortego ^[4] ; Erol,Fikrig ^[2] ; Luis,Martinez-Sobrido ^[3] ; Rafael,Blasco ^[1]

作者单位： Departamento de Biotecnología, INIA CSIC, Carretera La Coruña km 7.5, E-28040 Madrid, Spain. ^[1] Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06519, USA. ^[2] Texas Biomedical Research Institute, San Antonio, TX 78227, USA. ^[3] Centro de Investigación en Sanidad Animal, INIA CSIC, Carretera Valdeolmos a El Casar, Valdeolmos, E-28130 Madrid, Spain. ^[4] Departamento de Biotecnología, INIA CSIC, Carretera La Coruña km 7.5, E-28040 Madrid, Spain.;Centro de Investigación en Sanidad Animal, INIA CSIC, Carretera Valdeolmos a El Casar, Valdeolmos, E-28130 Madrid, Spain. ^[5] Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06510, USA. ^[6]

关键词 COVID-19 SARS-CoV-2 immunization modified vaccinia virus Ankara poxvirus recombinant viral vectors vaccine

DOI 10.3390/vaccines11051006

PMID 37243110

发布时间 2024-04-11

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Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models.

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Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models.

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