Efficacy, safety, and prognostic factors of PD-1 inhibitors combined with lenvatinib and Gemox chemotherapy as first-line treatment in advanced intrahepatic cholangiocarcinoma: a multicenter real-world study.

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作者： Chengpei,Zhu ^[1] ; Hu,Li ^[2] ; Xiaobo,Yang ^[1] ; Shanshan,Wang ^[1] ; Yunchao,Wang ^[1] ; Nan,Zhang ^[1] ; Yanyu,Wang ^[1] ; Jingnan,Xue ^[1] ; Longhao,Zhang ^[1] ; Cong,Ning ^[1] ; Xu,Yang ^[1] ; Ziyu,Xun ^[1] ; Jiashuo,Chao ^[1] ; Junyu,Long ^[1] ; Xinting,Sang ^[3] ; Zhenyu,Zhu ^[4] ; Haitao,Zhao ^[5]

作者单位： Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. ^[1] Department of Hepatobiliary Surgery, The Fifth Medical Center of PLA General Hospital, No. 100 Middle Road of West 4th Ring Road, Fengtai District, Beijing, 100039, China. ^[2] Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. sangxt@pumch.cn. ^[3] Department of Hepatobiliary Surgery, The Fifth Medical Center of PLA General Hospital, No. 100 Middle Road of West 4th Ring Road, Fengtai District, Beijing, 100039, China. zhuzy302@163.com. ^[4] Department of Liver Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), #1 Shuaifuyuan, Wangfujing, Beijing, 100730, China. zhaoht@pumch.cn. ^[5]

关键词 Advanced intrahepatic cholangiocarcinoma Gemox chemotherapy Lenvatinib PD-1 inhibitor Systemic therapy

主题词人类(Humans);回顾性研究(Retrospective Studies);预后(Prognosis);胆管上皮癌(Cholangiocarcinoma);胆管肿瘤(Bile Duct Neoplasms);胆管, 肝内(Bile Ducts, Intrahepatic)

DOI 10.1007/s00262-023-03466-8

PMID 37247023

发布时间 2024-09-26

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